Placental galectin-3 is reduced in early-onset preeclampsia

M Kandel; S Tong; SP Walker; P Cannon; TV Nguyen; TM MacDonald; NJ Hannan; TJ Kaitu’u-Lino; LA Bartho

Journal article

Placental galectin-3 is reduced in early-onset preeclampsia

M Kandel, S Tong, SP Walker, P Cannon, TV Nguyen, TM MacDonald, NJ Hannan, TJ Kaitu’u-Lino, LA Bartho

Frontiers in Physiology | FRONTIERS MEDIA SA | Published : 2022

DOI: 10.3389/fphys.2022.1037597

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Abstract

Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009)..

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Funding for this work was provided by: National Health and Medical Research Council (#1065854, 2000732). Salary support was received from the National Health and Medical Research Council Fellowships to TK-L (#1159261), ST (#1136418), and NH (#1160711 and #1146128).